Distant metastasis in triple-negative breast cancer
نویسندگان
چکیده
منابع مشابه
Rad51 supports triple negative breast cancer metastasis
In contrast to extensive studies on familial breast cancer, it is currently unclear whether defects in DNA double strand break (DSB) repair genes play a role in sporadic breast cancer development and progression. We performed analysis of immunohistochemistry in an independent cohort of 235 were sporadic breast tumours. This analysis suggested that RAD51 expression is increased during breast can...
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Osteoprotegerin (OPG) is a secreted member of the tumor necrosis factor (TNF) receptor superfamily that has been well characterized as a negative regulator of bone remodeling. OPG is also expressed in human breast cancer tissues and cell lines. In vitro studies suggest that OPG exerts tumor-promoting effects by binding to TNF-related apoptosis inducing ligand (TRAIL), thereby preventing inducti...
متن کاملRare metastasis to paranasal sinuses from triple-negative breast cancer
RATIONALE Breast cancer, the most common form of cancer among women, rarely metastases to the head and neck region. To date, there have been only 6 similar cases in the literature, and most patients in these reports had very poor prognosis. PATIENTS CONCERNS We report a 61-year-old female presented pain and numbness on the right side of the face 5 years after being diagnosed with triple-negat...
متن کاملTAB3 O-GlcNAcylation promotes metastasis of triple negative breast cancer
O-GlcNAcylation is a post-translational modification that regulates a broad range of nuclear and cytoplasmic proteins and is emerging as a key regulator of various biological processes. Although previous studies have shown that increased levels of global O-GlcNAcylation and O-GlcNActransferase are linked to the incidence of metastasis in triple negative breast cancer (TNBC) patients, the molecu...
متن کاملClinicopathological Features of Non-metastatic Triple Negative Breast Cancer
Background: Triple negative breast cancer (TNBC) is reported to be associated with a high risk of recurrence, poor overall survival (OS), and disease-free survival (DFS) rates. This study evaluated the clincopathological features and survival of non-metastatic TNBC women in the capital of Iran compared with other areas of the world. Methods: In a retrospective study, 119 women with TNBC based ...
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ژورنال
عنوان ژورنال: Neoplasma
سال: 2013
ISSN: 1338-4317
DOI: 10.4149/neo_2013_038